Opioid and Endocannabinoid System in Orofacial Pain
نویسندگان
چکیده
منابع مشابه
Role of opioid system in verapamil-induced antinociception in a rat model of orofacial pain
Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...
متن کاملrole of opioid system in verapamil-induced antinociception in a rat model of orofacial pain
calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. in the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. orofacial pain was induced by subcutaneous (sc) injection of for...
متن کاملThe endocannabinoid system and pain.
The therapeutic potential of cannabinoids has been the topic of extensive investigation following the discovery of cannabinoid receptors and their endogenous ligands. Cannabinoid receptors and their endogenous ligands are present at supraspinal, spinal and peripheral levels. Cannabinoids suppress behavioral responses to noxious stimulation and suppress nociceptive processing through activation ...
متن کاملRole of opioid system in verapamil-induced antinociception in a rat model of orofacial pain
Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...
متن کاملThe Endocannabinoid System, Cannabinoids, and Pain
The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB 1 receptors) and in the periphery (primarily but not exclusively CB 2 recep...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2019
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.934159